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Sculley and Langley-Evans demonstrated that the bacterium Porphyromona gingivalis , which destroys the connective tissue and bone around the tooth root, causes the release of interleukin 8 (IL-8) and TNF, leading to an increase in the number and activity of polymorphonuclears (PMNs), which cause the production of ROS as a host response to infection

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In the same group, severe nuclear pyknosis in neurons (arrows) of the substantia nigra (Fig

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J Biol Chem 285: 1902219028 GutscherM,PauleauAL,MartyL,BrachT,WabnitzGH,SamstagY,MeyerAJ,DickTP (2008) Realtime imaging of the intracellular glutathione redox potential