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it also eradicates existing , scars, e

To deliver oxygen to the tissues, erythrocytes must be able to dynamically adapt to and compensate for the constantly changing flow conditions along the vascular tree and particularly in the narrowest capillaries to deform significantly without rupturing

Subsequently, caspase-1 cleaves GSDMD, releasing the GSDMD-NT fragment, which induces pore formation, cell swelling, and ultimately pyroptosis [82]

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However, as the disease progresses, sustained abnormal glial activation triggers the overactivation of signaling pathways such as NF-B and p38 MAPK, leading to the excessive release of pro-inflammatory cytokines (e.g., IL-1, TNF-, IL-6) (Newcombe et al., 2018