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[9] Phytophotodermatitis can affect people of any age

Although the exact mechanism of action remains to be elucidated, the main mechanism includes inhibition of cyclooxygenase and lipoxygenase, subsequently leading to reduced production of prostaglandins and leukotrienes, respectively [25]

In addition, the abnormal expression of von Willebrand factor (vWF, a biomarker of endothelial injury) in iliac veins was significantly inhibited by nanotherapies (Fig