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When tissue is injured, fibroblasts travel to the site of the injury to facilitate the healing process.) Increases VEGF 2, which improves angiogenesis (the formation of blood vessels) and neurological remodeling

Why It Was in Category 2 Despite decades of clinical use in Russia (where it is an approved pharmaceutical), Semax was placed in Category 2 in the US due to safety concerns, likely related to the limited data from US-standard clinical trials and the regulatory gap between international evidence and FDA requirements

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Results: Immediately post-injury, and at 1, 2, 3, 5, 7, 14, 21, 28, 60, and 90 days post-injury, quadriceps muscle-to-bone detachment showed definitive healing failure (impaired walking and permanent knee flexure)