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S., Umar, H., & Alamiery, A

doi: 10.1016/j.cellbi.2004.11.024 43 ZhouMWangDTangJ

The body produces an enzyme called telomerase, which can help maintain or extend telomeres in certain cell types

The structural basis for orforglipron's mechanism was published in the Proceedings of the National Academy of Sciences in 2020, revealing through cryo-electron microscopy (cryo-EM) how a small molecule could stabilize the active conformation of a class B GPCR, a finding that fundamentally changed the field's understanding of GPCR pharmacology