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After treatment of drug-resistant tumor cell lines, MCF7/TH, HCT116R and A549/ADR, with curcumin, ROS levels and expression of apoptotic markers, such as Bax and cytochrome c, were notably increased in the high-dose group compared to the low-dose group (25)

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This confirms earlier reports that such interactions between GSH and metallothioneins occur, highlighting the relationship between these two compounds that depends on the cells redox state (Zalewska et al