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PAR-1 to -4, with PAR-1 being the most potent receptor for thrombin

"Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract." Current Pharmaceutical Design

pulsatility as well as sustained, dose-dependent increases in [growth hormone] and IGF-I levels in healthy adults.11 9 In 1999, a human trial with 40 total volunteers concluded that ipamorelin at multiple doses induces growth hormone secretion at sufficient levels to be biologically effective, with peak concentration arriving within an hour.12 These studies examined the two peptides separately, but their results validate the mechanisms of action that underlie the reason that CJC-1295 and ipamorelin are used together

For RNAi drugs, challenges include safety, efficacy, and delivery issues