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Description

From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).

Rastogi et al

Additionally, specific cases of HGSOC exhibit overexpression of proto-oncogenes such as AKT and ERRB2

2024a, b, c

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