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Without being bound by theory, it appears that Dihexa binds HGF better than HGF itself forming an active heterodimer of HGF:Dihexa

Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)