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A recent systematic review and meta-analysis highlighted the high global prevalence of diabetic foot ulceration among DPN patients, emphasizing the critical need for early detection and comprehensive management strategies to prevent severe outcomes

Symptoms of opioid withdrawal include dysphoria, restlessness, lacrimation, rhinorrhea, myalgias, arthralgias, and GI distress including nausea, vomiting, abdominal cramping, and diarrhea

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The brain has a high demand for GSH due to its high metabolic activity and vulnerability to oxidative stress, which can lead to neurodegeneration and cognitive decline