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The translocation of toxic Pb from the environment to crop grains [19], indicates that Pb toxicity rapidly spreads from the environment to food chains

Meanwhile, Acyl-coA synthetase long-chain family member 4 (ACSL4) esterifies PUFAs into phospholipids, expanding the pool of oxidizable substrates, while the 15-lipoxygenase(15-LOX)/phosphatidylethanolamine-binding protein 1 (PEBP1) complex catalyzes the formation of specific peroxidized PE species, serving as a persistent source of ROS [145]

Notably, the administration of cisplatin and paclitaxel can enhance the secretion of exosomal miR-522 by activating the USP7/hnRNPA1 axis in CAFs

Conclusion and perspective In summary, DNA methylation, histone modification, m6A modification and other epigenetic modifications play a role in regulating different death modes of tumor cells, such as pyroptosis, ferroptosis and cuproptosis

Ann Oncol 1997;8(6):569-573