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In addition, glucocorticoids have been found to indirectly increase mitochondrial respiration by inhibiting glycolytic activity

Additionally, several studies indicate that although most metabolic changes show common trends in both UC and CD, distinct patterns can also be identified: for example, alterations in the bile acid pool, such as differential shifts in primary versus secondary bile acids

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Surprisingly, when present in the brain, the HERV-K ENV protein reproduced the previously reported BBB dysfunction observed in ALS brains, which was also prevented by GNK-301

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