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55,56 Usually, eGFR is estimated using the blood creatinine level

It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)

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Notably, localized mechanical rupture, membrane perforation, and pressure-induced deformation collectively undermine the structural integrity of microbial cells