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Clinical trials are underway for GLS inhibitors such as CB839 (NCT02071862, NCT02071888, and NCT02071927), as well as OXPHOS inhibiting molecules like atovaquone, metformin, IACS010759, and phenformin NCT03291938, NCT03026517, NCT01101438 and NCT03568994) [336, 337, 338]

Although existing literature has clarified the core role of RPE cell ferroptosis in DR progression and preliminarily elucidated the regulatory mechanisms of iron homeostasis imbalance, lipid peroxidation and related molecular axes, multiple limitations remain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Ng J.H.Y., Andersen J

Nat Genet 35(4):349356 Ho TY, Lo HY, Liu IC, Huang SL, Hsiang CY (2022) Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction