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Moreover, although some EoE patients exhibit elevated plasma immunoglobulin E (IgE) or blood IL-5R levels, IgE-targeted therapies for food allergy (omalizumab) and IL-5-/IL-5R -targeted therapies for asthma (benralizumab, mepolizumab, reslizumab) have proven ineffective for EoE ( In conclusion, while plasma GPX activity may not help identify EoE across ages, it may serve as a biomarker for atopic inflammation, particularly in pediatric patients