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Cited 8/3/24 Vanderah TW (2024): Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs

10.3390/pharmaceutics13040508 161 SilvaA

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ

Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations

High doses of Put (2.5 mM) can induce mild metabolic stress, e.g., by increasing the production of HO as a byproduct of amine oxidation and shifting metabolic pathways towards proline synthesis 66