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Excessive ROS levels are known to foster carcinogenesis by intensifying oxidative stress and augmenting the frequency of DNA mutations (124)

95%CI=1.94-3.60) and previous CAD (HR=7.85

MYC mediates PHGDH activation, which enhances GSC self-renewal by regulating redox homeostasis, promoting on-carbon metabolism and facilitating the DNA damage response via SSP activation, thereby driving GSC malignant progression and radioresistance in GBM (64)