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As previously discussed, tobacco smoke is a mixture of substances exhibiting varying abilities to induce or inhibit the activity of hepatic detoxifying enzymes, as well as other transporters involved in the elimination of xenobiotics

Clinical Implications and Future Directions The clinical effects of G6PD deficiency on the heart remain largely unexplored despite it being the most common known enzyme deficiency in the world (12)

1,219 Aromatase inhibitors are generally well tolerated but can trigger side effects including decreased libido, headache, hot flashes, weight gain, and insomnia, as well as liver enzyme elevation and bone loss

Sleep, Circadian Hormonal Dysregulation, and Breast Cancer Survival (NCT00519168) and the French Awareness About Breast Cancer Screening (NCT03777397) are linking epidemiologic findings with biological and behavioral pathways

VDR and TM are supported by the Strategic Academic Leadership Program of Southern Federal University, known as Priority 2030, and the Ministry of Science and Higher Education of the Russian Federation (grant number: FENW-2023-0008)