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Fibroblast activation protein (FAP)-targeted zinc ferrite nanoparticles accumulated in FAP-expressing synovial fibroblasts in a rheumatoid arthritis model by activating ER stress and mitochondrial dysfunction, resulting in controlled cytotoxicity in inflamed joints, sparing healthy tissue 179,180

Statistical analysis of Superplots was calculated on the basis of the average values of each experiment (large symbols)

6-hydroxydopamine (6-OHDA) is a commonly used neurotoxin that resembles catecholamines and is recognized by DA and NE transporters

However, increasing non-ionic surfactants and cholesterol beyond optimal levels (above 30 mg) led to reduced entrapment efficiency and larger particle sizes in niosomes, likely due to disrupted vesicular structures and potential formation of mixed micelles 56,57