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8 Consistent with prior studies showing that AHCY inhibition disrupts the methionine cycle, lowers SAM levels, and reduces tumor burden in Apc-deficient intestinal tumor models 9 an effect corroborated by AHCY-knockout mice generated by Liao et al

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their enhanced glycolytic metabolism increases lactate production, further exacerbating oxidative stress (32)

The tumors with the highest rates of ID were pancreatic (63%), colorectal (52%), and lung cancers (51%) (124, 125)