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The latest research reveals CGRP-mediated transcriptional reprogramming of dendritic cells, enhancing their sentinel capacity through upregulation of interferon-response genes (e.g., pro-IF-1) while priming proinflammatory cytokine cascades via calcium-dependent depolarization

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CAR-T cell source and culture duration determine efficacy and safety across oncology and AID, with shorter ex vivo culture yielding less differentiated CAR-T cells that exhibit enhanced effector function and proliferative capacity, especially beneficial for sustained immune regulation in AID (118)

Chien CY, Tai SY, Wang LF, et al

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