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Cyclophosphamide , an alkylating agent, exerts its cytotoxicity by forming DNA cross-links and is used in breast cancer, lymphomas, and autoimmune malignancies

Targeted delivery minimizes systemic exposure and focuses action on the tissue that requires repair, reducing off-target proliferation risk

Neurons of the CNS are very active in oxidative metabolism, as they are constantly exposed to lowtomoderate levels of ROS, and these species are removed by antioxidants (melatonin, vitamin D, vitamin E, glutathione) and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, etc.)