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Senescent TECs upregulate cyclin-dependent kinase inhibitor 2 A (p16), 1B (p27), and 1 A (p21) and secrete diverse cytokines and growth factors via the SASP

For example, in the cuprizone-induced demyelination mouse model of MS, the KD led to increased activity of glutathione peroxidase, an enzyme that breaks down H 2 O 2 , and reduced expression of the oxidative stress marker malondialdehyde

1a, ALP and ARS staining showed that ALP activity and mineralization were enhanced in an NAM dose-dependent manner, and 10 M NAM had the greatest effect on osteoblast differentiation (Fig

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