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Moreover, rapamycin upregulated Wnt/-catenin signaling, including statistically significant upregulation of the T cell memory genes TCF7, LEF1, FOXO1 in rapamycin-treated products (Supplementary Data 5b)

extract could theoretically protect residual melanocytes from oxidative stress and stabilize the local epidermal environment, a foundational step for any repigmentation strategy

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This condition can be reversed by pharmacologically activating AMPK or overexpressing NMT1, which will restore metabolic balance (154)