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In the case of certain substrates (eg benzyl and phenethyl isothiocyanates, alkyl dihalides), GST can catalyse both the forward and reverse reactions, leading to increased toxicity rather than detoxication [3]

doi: 10.1080/10409238.2019.1570075 102 KangH.OkaS.LeeD

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Safety is dose, delivery, and patient selection dependent, so implement mitigation measures including baseline screening, slow dose escalation, and monitoring for immune reactions or aberrant tissue growth