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For single-site systems, biphasic kinetics may arise when one active site binds two substrate molecules: the first binding saturates (low K M1 , low V max1 ), while the second does not saturate (high K M2 , high V max2 ) due to experimental constraints (e.g., substrate solubility), modeled by Eq

4a) and converted to corresponding genes, which were then cross-referenced with psoriasis-related genes from GeneCards and OMIM

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Physiol Rev 98(3):11691203 Zhou J, Zheng Q, Chen Z (2022) The Nrf2 pathway in liver diseases