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Furthermore, a randomized clinical trial demonstrated that combining daptomycin with fosfomycin for MRSA bacteremia resulted in a 12% higher success rate compared to daptomycin alone, and led to a 17.8% reduction in mortality in vancomycin-resistant Enterococcus bloodstream infections (Pujol et al., 2021)

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The study reported no significant toxicity, apart from gastrointestinal symptoms (diarrhea, nausea, and flatulence) which were managed symptomatically with minimal impact on quality of life 97

[PubMed] [Google Scholar] 77.Whitehead RE, Ferrer JV, Javitch JA, Justice JB

By blocking the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, curcumin prevents the generation of highly inflammatory lipid mediators like leukotrienes (LTC4) and prostaglandins (PGD2)