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TRPM2 mediates hepatic ischemia-reperfusion injury via Ca(2+)-induced mitochondrial lipid peroxidation through increasing ALOX12 expression

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36 159 A recent proteomics and genomics analysis revealed that the protein expression levels of ALDH1B1, ALDH2, and ALDH3B1 are reduced, indicating the loss of liver-specific metabolic functions in patients with HBV-related HCC, and that this reduction may promote tumor progression by increasing the accumulation of exogenous compounds

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the results revealed that HDAC1-3 and SIRT1-3 reduced histone (including H3K18 and H4K5) Kla and that HDAC3 was the most potent eraser of Kla 99