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Some healthcare professionals might prescribe a low-dose, low-frequency regimen of Accutane as an off-label treatment, meaning the FDA has not reviewed the risks of taking Accutane at a low dose over a long period

2019 Sep 15;15(9):1365-1367

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Endocrinologa y Nutricin (English Edition) 59(8):487490 Reinstatler L et al (2012) Association of biochemical B 12 deficiency with metformin therapy and vitamin B 12 supplements: the National Health and Nutrition Examination Survey, 19992006