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Examination of enzyme activity showed the complete absence of neutral cholesteryl ester hydrolase activity in adipose tissue, both WAT and BAT

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routine B12 level monitoring is generally unnecessary once replacement is established, as levels do not reliably correlate with tissue stores Important safety considerations: Older adults may have impaired renal function, though this rarely affects B12 therapy given its wide safety margin

For example, parameters that have been shown in other studies to alter cecal and fecal microbiomes (e.g., vendor source 62,63 ) were consistent across experimental groups in this study