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Finally, the timeline conversation is where most secretagogue interest collides with biology

10.1016/j.exer.2023.109740 229

Low dopamine with excessive norepinephrine drive Medication clue: bupropion, amphetamine or an SNRI may improve motivation but worsen panic, insomnia, irritability or palpitations because they also raise norepinephrine

Dis Model Mech 11(8):dmm035758 Mukhopadhyay S, Goswami D, Adiseshaiah PP et al (2020) Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers