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TET1, TET2, and TET3 can subsequently oxidize 5-hmC into 5-formylcytosine and 5-carboxylcytosine ( via the base excision repair (BER) pathway ( Alcohol induces DNA hypomethylation in the liver By altering the activity and expression of enzymes involved in one-carbon metabolism, such as methionine synthase, methionine adenosyltransferase, and betaine-homocysteine methyltransferase, alcohol consumption decreases the methylation index in the liver ( Ethanol also reduces dietary folate absorption by altering the binding and transport kinetics of the folate transport system and reducing the expression of folate transporters in the intestines and kidneys (26)

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*Correspondence: Wim J

10.1073/pnas.0501536102 Proc

Overall, the metabolomics results of these published cerebrospinal fluid investigations of a wide range of disease conditions did not match our ME/CFS cerebrospinal fluid pattern of disordered serine pathways with sarcosine and phospholipid production, folate and one carbon exchange, purine, pyrimidine, aromatic and anaplerotic amino acid metabolism