glutathione peroxidase on gsh levels ncbi Genetic Analysis of in Oxidative Stress Response of Saccharomyces cerevisiae * Several lines of antioxidant defense

10.1038/s41398-017-0031-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Yang J.-Z., Zhang K.-K., Liu Y., Li X.-W., Chen L.-J., Liu J.-L., et al

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TNFR-1 exerts a negative influence on hippocampal adult neurogenesis,656667 whereas TNFR-2 is involved in promoting neurogenesis.6869 TNF- is also closely associated with synaptic plasticity by inducing -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that mediate glutamatergic activity.70 Because human neural stem cells have both TNFR-1 and TNFR-2, whether neurogenesis is enhanced or inhibited depends on the microenvironment in the CNS and the context of insults

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This view suggests that excessive mitophagy might lead to loss of functional mitochondria, thereby exacerbating energy deficits and triggering apoptotic pathways