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PEG conjugation also improves peptide solubility by introducing hydrophilic chains that interact with water and mask hydrophobic regions, while minimising aggregation through steric hindrance that limits intermolecular interactions

Hunter CW, Guyer R, Froimson M, DePalma MJ: Effect of Age on Outcomes after Allogeneic Disc Tissue Supplementation in Patients with Chronic Discogenic Low Back Pain in the VAST Trial

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