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Additionally, compared to the healthy group, the T2DM group has significantly increased levels of the proinflammatory cytokine IL-6 and decreased levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) in the plasma samples

The two melanocortin peptides, -MSH and ACTH, are the agonists of MC1R and are both derived from the same precursor, called pro-opiomelanocortin (POMC), by proteolytic cleavage [31]

The cases of nephropathy and proteinuria are rare in humans susceptibility towards such condition based on the genetic makeup of the individual

doi: 10.1016/j.bbagen.2013.07.009