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In the hypoxic environment, activation of the HIF-1/BNIP3 pathway induced BNIP3-associated mitophagy

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Studies have shown that FAM134B deficiency renders cells more susceptible to apoptosis and is associated with hereditary sensory and autonomic neuropathy type IIB (HSAN IIB) [28]

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This shifting metabolic state is why blanket antioxidant supplementation without baseline assessment may not align with individual needs and could theoretically interfere with adaptive cellular responses to the medication

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Currently, there are two main strategies for targeting copper in cancer treatment

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