igf-1/cjc-1295/ipamorelin

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10.7554/eLife.67452 37 FangZ.LiuK

Taken together, tumors may inactivate TSGs via three primary mechanisms involving NMD: (1) combining PTC-bearing alleles with heterozygous deletions, (2) exacerbating haploinsufficiency via degradation of mutant transcripts, and (3) generating dominant-negative proteins from NMD-insensitive transcripts [118,119,120,121,122]