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doi:10.1152/physrev.00004.2022 Memorial Sloan Kettering Cancer Center

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Temperature management matters more than injection technique, more than timing, and more than any other variable in the administration process

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It was first suggested that importation of StAR into mitochondria formed contact points between the OMM and IMM, permitting cholesterol to flow down a chemical concentration gradient (136, 199), and others concluded that the 30 kDa mature StAR is the biologically active moiety, functioning as a cholesterol shuttle in the intramembranous space (207)