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It conjugates electrophilic compounds through glutathione S-transferases to form water-soluble products for cellular elimination

When used on its own, the maximum dosage is 4.5 mg weekly, whereas in combination with semaglutide, the dose is capped at 2.4 mg per week [10, 11]

The activity and stability of key enzymes in the SSP are precisely regulated by transcription factors (such as c-Myc, HIF-1, and NRF2), epigenetic modifications (including m5C and m6A), and post-translational modifications (such as methylation, ubiquitination, and deacetylation)

By these mechanisms, it reduces new melanin synthesis and erythema

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