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When this is found, consideration should be given to the possibility of any one of a number of rarely encountered conditions such as Peutz-Jehgers syndrome, Laugier-Hunziger syndrome, Bannayan-Riley-Ruvalcaba syndrome, LEOPARD syndrome, and the several syndromes in which lentigines and cardiocutaneus myxomas are found

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"Overall, it's just such a sign of the misinformation that is being propagated, the misinformation problem is getting bigger and bigger," she said

In our experience, when pagetoid spread is present, it is usually limited to small numbers of cells and restricted to the lower layers of the epidermis