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Neurodegeneration and inflammation in Parkinson's disease

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In stressed neutrophils, during an oxidative burst, glycolysis is shifted to the PPP, allowing the neutrophils to promptly mount a first line of defense against pathogens, using the generated NADPH for redox signaling ( 5.1.4 Oxidative phosphorylation Despite possessing intact mitochondria and a functional TCA cycle, mature neutrophils exhibit minimal reliance on mitochondrial respiration for their energy production (Rodrguez-Espinosa et al., 2015), since the inhibition of mitochondrial respiration had no impact on ATP generation in mature neutrophils (Maianski et al., 2004)

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Implication of free radicals and glutathione in the mechanism of cadmium-induced expression of stress proteins in the A549 human lung cell-line

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Intracellular NO production inhibition prevents the hypersecretion of mucin that is stimulated by ROS and other inflammatory mediators (27)

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