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NAC is known to increase the cellular content of GSH 18 and it is used in the treatment of SOS and hepatotoxicity caused by acetaminophen 19,20

Small fibre polyneuropathy can result not only in neuropathic pain and other sensations such as pins and needles or itching but also, interestingly, in a very wide range of (familiar) autonomic symptoms including (but not restricted to) dry eyes, dry mouth, orthostatic dizziness, constipation, bladder incontinence, sexual dysfunction, trouble sweating etc (Tavee, Zhou, 2009)

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Both authors read and approved the final version of the manuscript

Grace, Columbia, MD, USA), and on an XBridge ethylene bridged hybrid HILIC column (Waters, Milford, MA, USA) for urine