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Conditional deletion of the mitochondrial transcription factor A (Tfam) in CD4 + T cells led to an imbalance in the NAD + /NADH ratio of mitochondria, which induced metabolic reprogramming toward glycolysis and thereby contributed to their pro-inflammatory phenotype, consequently exacerbating the in vivo immune response

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[DOI] [PubMed] [Google Scholar] 27.Bhattacharya P., Jacks G., Ahmed K.M., Routh J., Khan A.A