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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

2 Consider high-dose oral therapy where absorption is intact

AOD-9604 research peptide

Medicare paid $313 million for 3.3 million intravitreal injections in that window

The reality we see consistently: researchers who combine AOD-9604 and 5-Amino-1MQ with structured fasted-state administration and exercise timing report reductions in subcutaneous adipose depots that single-agent protocols rarely match, even at higher doses