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However, as detailed above, cells that exhibit higher levels of mitochondrial activity are less sensitive to 5FU treatment, and those with compromised mitochondrial function are more sensitive, correlating with intrinsic resistance

On the other hand, FoB rely on OXPHOS to a lower extent: Gclc -deficient FoB lose CI and CII functionality, but these cells increase glycolysis to replenish their ATP pool to the extent that they persist in Gclc fl/fl Mb1 Cre + hosts

PMID: 9168303

Just like when they said margarine was better for us than butter

third, summarizing potential effective therapeutic agents and subtype-matched clinical strategies based on core molecular targets