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15 Conclusions and future perspectives Glutathione (GSH) plays a paradoxical role in cancer biology Table 4, acting both as a protective shield for tumor cells and as a therapeutic vulnerability that can be exploited for precision medicine

humans depend on dietary antioxidants to reduce free radical concentrations [37]

Pyroptosis is a form of programmed cell death associated with an inflammatory response that involves the activation of caspases that process gasdermin (GSDM), allowing pore formation on the plasma membrane and the subsequent release of damage-associated molecular patterns, such as high-mobility group box 1 (HMGB1)

Shared and distinct mechanisms of fibrosis

Blood 128 , 158 (2016)