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Since the magnitude and persistence of cAMP increments and decrements are enhanced during different hunger states, it is unlikely that a global state such as arousal dictates the overall magnitude and persistence of peptidergic signaling (Figure 5A)

research is supported by funding from ZJU 100 Young Professor Project, Rut and Arvid Wolff Memorial Foundation (2023-02467), ke Wiberg Foundation (M19-0266), Fredrik and Ingrid Thuring Foundation (2019-00488)

Heinonen are thanked for their excellent technical assistance, and likewise the Turku Bioscience Proteomics core facility, supported by the University of Turku, bo Akademi University and Biocenter Finland

The observations of the present study and previous safety evaluation and pharmacodynamic research will provide basic information for further comprehensive clinical research

doi: 10.2478/bjmg-2014-0070 213 RuzickaW