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Description

Clinical review 90: Leptin and clinical medicine: a new piece in the puzzle of obesity

Materials and Methods 2.1

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The model of zebrafish has been also used for group-3 MB cells (130) to identify the subgroup MB cellular origin (131), to mimic the SHH-MB with specific mutations (132), to generate transcription activator-like effector nucleases TALEN-mediated somatic gene inactivation of CDKN2A/B or RB1 tumor suppressor genes (133)