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Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids

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Medications to Increase Sperm Count, Morphology, and Overall Male Fertility Clomiphene Citrate (Clomid) Clomid, the brand name for clomiphene citrate (CC), is one of the most widely used off-label medications for male infertility, even though it is not FDA-approved for men

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The body essentially adapts to the presence of the signaling molecule and requires increasingly higher doses to achieve the same effect