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A number of studies report that flavokavains A and B are the most cytotoxic compounds identified in kava [152], and one study particularly demonstrated its toxicity towards cells of liver origin and showed that they increased the cellular level of AST, indicative of potential liver toxicity [188]

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Statistical analysis Statistical analysis was performed with the Statistica 13.3 package (TIBCO Software Inc., Palo Alto, CA, USA)